Journal of Pathology and Translational Medicine

Original Article

Preoperative Cytologic Diagnosis of Warthin-like Variant of Papillary Thyroid Carcinoma: Jisup Kim, Beom Jin Lim, Soon Won Hong, Ju Yeon Pyo; J Pathol Transl Med. 2018;52(2):105-109. Published online February 12, 2018; DOI: https://doi.org/10.4132/jptm.2017.12.26

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Background
Warthin-like variant of papillary thyroid carcinoma (WLV-PTC) is a relatively rare variant of papillary thyroid carcinoma with favorable prognosis. However, preoperative diagnosis using fine-needle aspiration (FNA) specimens is challenging especially with lymphocytic thyroiditis characterized by Hürthle cells and lymphocytic background. To determine a helpful cytological differential point, we compared WLV-PTC FNA findings with conventional papillary thyroid carcinoma with lymphocytic thyroiditis (PTC-LT) and conventional papillary thyroid carcinoma without lymphocytic thyroiditis (PTC) regarding infiltrating inflammatory cells and their distribution. Preoperative diagnosis or potential for WLV-PTC will be helpful for surgeons to decide the scope of operation.
Methods
Of the 8,179 patients treated for papillary thyroid carcinoma between January 2007 and December 2012, 16 patients (0.2%) were pathologically confirmed as WLV-PTC and four cases were available for cytologic review. For comparison, we randomly selected six PTC-LT cases and five PTC cases during the same period. The number of intratumoral and background lymphocytes, histiocytes, neutrophils, and the presence of giant cells were evaluated and compared using conventional smear and ThinPrep preparations.
Results
WLV-PTC showed extensive lymphocytic smear with incorporation of thyroid follicular tumor cell clusters and frequent histiocytes. WLV-PTC was associated with higher intratumoral and background lymphocytes and histiocytes compared with PTC-LT or PTC. The difference was more distinct in liquid-based cytology.
Conclusions
The lymphocytic smear pattern and the number of inflammatory cells of WLV-PTC are different from those of PTC-LT or PTC and will be helpful for the differential diagnosis of WLV-PTC in preoperative FNA.

Citations

Citations to this article as recorded by

Warthin-like variant of papillary thyroid carcinoma with lymph node metastases: a case report and review of the literature
Andrii Hryshchyshyn, Andrii Bahrii, Pavlina Botsun, Volodymyr Chuba
Journal of Medical Case Reports.2024;[Epub] CrossRef
Warthin-like papillary thyroid carcinoma: a case report and comprehensive review of the literature
Abdel Mouhaymen Missaoui, Fatma Hamza, Wafa Belabed, Manel Mellouli, Mohamed Maaloul, Slim Charfi, Issam Jardak, Tahya Sellami-Boudawara, Nabila Rekik, Mohamed Abid
Frontiers in Endocrinology.2023;[Epub] CrossRef
The Warthin-like variant of papillary thyroid carcinomas: a clinicopathologic analysis report of two cases
Xing Zhao, Yijia Zhang, Pengyu Hao, Mingzhen Zhao, Xingbin Shen
Oncologie.2023; 25(5): 581. CrossRef
Challenges in Cytology Specimens With Hürthle Cells
Eleni Thodou, Sule Canberk, Fernando Schmitt
Frontiers in Endocrinology.2021;[Epub] CrossRef
Warthin-like variant of Papillary thyroid carcinoma—Case report of an uncommon tumour with review of literature
Pradyumna Kumar Sahoo, Rashmi Patnayak, Perwez Alam Khan, Amitabh Jena
International Journal of Surgery Case Reports.2020; 77: 9. CrossRef

Case Study

A Rare Case of Aggressive Melanotic Schwannoma Occurred in Spinal Nerve of a 59-Year-Old Male: Sung-eun Choi, Yoon Jin Cha, Jisup Kim, Hyunseo Cha, Jayeong Seo, Sung-Uk Kuh, Sung-Jun Kim, Se Hoon Kim; J Pathol Transl Med. 2017;51(5):505-508. Published online April 4, 2017; DOI: https://doi.org/10.4132/jptm.2017.01.04

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Abstract PDF

Melanotic schwannoma (MS) is a rare variant of nerve sheath neoplasm that shows ultrastructural and immunophenotypical features of Schwann cells but also has cytoplasmic melanosomes and is reactive for melanocytic markers as well. Unlike conventional schwannoma, which is totally benign, MS has an unpredictable prognosis and is thought to have low-malignant potential. Herein, we present a rare case of recurrent MS in lumbar spine of a 59-year-old male.

Citations

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Orthopaedic Surgery.2023; 15(2): 655. CrossRef
Sporadic spinal psammomatous malignant melanotic nerve sheath tumor: A case report and literature review
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Frontiers in Oncology.2023;[Epub] CrossRef
Case Report: Cutaneous melanocytic schwannoma with concomitant melanocytoma in a canine
Olwam H. Monakali, Nicolize O'Dell, Louise van der Weyden
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Yu‐Hua Huang, Ying‐Chou Lu, Hsuan‐Ying Huang, Chien‐Chin Chen
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Jyoti Bajpai, Akhil Kapoor, Rakesh Jalali, Mrinal M Gounder
BMJ Case Reports.2021; 14(5): e240296. CrossRef
18F-FDG PET/CT imaging for aggressive melanotic schwannoma of the L3 spinal root
Xun-Ze Shen, Wei Wang, Zhou-Ye Luo
Medicine.2021; 100(8): e24803. CrossRef
Hemorrhagic spinal melanotic schwannoma presenting as acute chest pain: A case report and literature review
Dallas J. Soyland, Dylan R. Goehner, Kayla M. Hoerschgen, Troy D. Gust, Shawn M. Vuong
Surgical Neurology International.2021; 12: 164. CrossRef
Retroperitoneal Recurrence of Melanotic Schwannoma on 18F-FDG PET/CT
Xiangliu OuYang, Lichun Zheng, Xiaoming Zhang
Clinical Nuclear Medicine.2021; 46(12): 991. CrossRef
Schwannoma originating from the common iliac artery: a case report
Seung-Myoung Son, Chang Gok Woo
Journal of International Medical Research.2020; 48(2): 030006051984979. CrossRef
Intraosseous Melanotic Schwannoma in the Sacrum Mimicking Primary Bone Tumor
Yoshitaka Nagashima, Yusuke Nishimura, Kaoru Eguchi, Takayuki Awaya, Satoshi Yoshikawa, Shoichi Haimoto, Toshihiko Wakabayashi, Masahito Hara
NMC Case Report Journal.2020; 7(3): 107. CrossRef
Extramedullary melanotic schwannoma recurrence in the cervical vertebral arch: a case report and review of the literature
Zongbin Hou, Teng Shi, Guangrun Li, Lin Tian, Xinna Li, Xiaoyang Liu
Journal of International Medical Research.2020; 48(8): 030006052094791. CrossRef
Extramedullary malignant melanotic schwannoma of the spine: Case report and an up to date systematic review of the literature
Georgios Solomou, Adikarige Haritha Dulanka Silva, Adrianna Wong, Ute Pohl, Nikolaos Tzerakis
Annals of Medicine and Surgery.2020; 59: 217. CrossRef
Melanotic Schwannoma of the Vagina: A Report of a Very Rare Tumor and Review of the Literature
Kofi Effah, Stefan Seidl, Edith Gorges, Patrick Kafui Akakpo
Case Reports in Obstetrics and Gynecology.2019; 2019: 1. CrossRef
Melanotic Schwannomas Are Rarely Seen Pigmented Tumors with Unpredictable Prognosis and Challenging Diagnosis
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Case Reports in Pathology.2017; 2017: 1. CrossRef

Brief Case Report

Metastatic Endobronchial Adenocarcinoma from the Uterine Cervix Verified by Human Papillomavirus Genotyping: Jisup Kim, Sungsoo Lee, Heae Surng Park; J Pathol Transl Med. 2015;49(2):174-176. Published online March 12, 2015; DOI: https://doi.org/10.4132/jptm.2015.02.10

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